Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 5th International Conference on Organic and Inorganic Chemistry Paris, France
Venue: Holiday Inn Paris Marne La Vallee.

Day 2 :

Keynote Forum

Don M Coltart

University of Houston, USA

Keynote: Stereocontrolled synthesis of chiral N- and O-heterocycles

Time : 09:30-10:15

OMICS International Organic and Inorganic Chemistry 2018 International Conference Keynote Speaker Don M Coltart photo
Biography:

Don M Coltart has obtained his Master’s degree from the University of Manitoba under the supervision of Professor James L Charlton and then joined the research group of Professor Derrick L J Clive at the University of Alberta where he obtained his PhD. His Post-doctoral work was conducted at the Memorial Sloan-Kettering Cancer Center as NSERC, AHFMR, and CRI Scholar under the supervision of Professor Samuel J Danishefsky. He began his independent career at Duke University in 2004 and moved to the University of Houston in 2012 where he is an Associate Professor. His research group studies the development of methods for asymmetric carbon–carbon bond formation, the application of those methods to the total synthesis of structurally complex biologically active natural products and the study of those compounds in biological systems.

Abstract:

Nitrogen heterocycles are among the most important structural motifs found in natural products, drugs and related compounds. While many nitrogen-containing natural products contain chiral nitrogen heterocycles, relatively few drugs do despite being chiral themselves. In the latter case, this limitation is due in large part to a lack of reliable, effective and broadly applicable methods for the preparation of such heterocycles. However, as drug development moves away from the use of unsaturated (flat), structurally simple achiral compounds and seeks out more stereochemically sophisticated chiral compounds having higher degrees of saturation, the need for methods for the synthesis of chiral nitrogen/oxygen heterocycles has become increasingly important. In response to this, we have undertaken a research program aimed to the use of dipolar 3-heterofunctionalized azoalkenes for the synthesis of various saturated and partially saturated chiral nitrogen/oxygen heterocycles via novel annulation strategies. In this seminar, we will describe a variety of methods that we have been developed for the preparation of different 3-hetero-functionalized azoalkenes and their use in dipolar coupling reactions leading to a range of chiral nitrogen/oxygen heterocycles.

Keynote Forum

Richard M. W. Wong

National University of Singapore, Singapore

Keynote: Application of Halogen Bonding to Organocatalysis

Time : 10:15-11:00

OMICS International Organic and Inorganic Chemistry 2018 International Conference Keynote Speaker Richard M. W. Wong photo
Biography:

Richard Wong received his Ph.D. degree from Australian National University in 1989. Subsequently, he held postdoctoral position at IBM Kingston and Yale University. Currently, he is a full professor and head of department at the National University of Singapore. He was the recipient of Fukui Award recently on his outstanding work in theoretical and computational chemistry. Richard has published about 200 scientific publications, which received over 9300 citations and H-index of 43. His research interests include application of computational quantum chemistry to a range of chemical problems, include reactive intermediates, catalysis, materials design, chemical sensors, and weak intermolecular interactions. He is an international advisory board member of Asian Journal of ChemistryJournal of Analytical and Applied Pyrolysis and Advanced Theory and Simulations.

Abstract:

Halogen bond, a noncovalent interaction involving a halogen atom as an acceptor of electron density, has emerged in recent years as an important element of molecular recognition and has numerous applications such as molecular self-assembly of functional materials and protein-drug interaction. Due to its bond strength and directionality, halogen bonding has great potential to become a complementary molecular tool to hydrogen bonding in rational catalyst design. Using density functional calculations, we have shown the use of halogen-bond donors as noncovalent activators in Lewis acid catalysis. In particular, we have proposed a new type of triaryl benzene organocatalysts via multiple halogen bond donors (e.g. perfluoro-iodophenyl group). This in silico designed halogen bonding (XB) based catalyst was applied to several important types of organic reaction, namely Diels-Alder reaction, Claisen rearrangement and cope-type hydroamination. The calculated catalytic mechanisms and activation barriers of these reactions readily demonstrate that the designed system is a promising Lewis acid catalyst via halogen bond mode of activation.[1] On the basis of our DFT calculations and calculated turnover frequencies, the XB-catalyzed reactions are found to be competitive with the corresponding hydrogen bonding catalysis reported in literature. The calculated transition states unravel multiple halogen bonds between the iodine atoms and various types of halogen bond acceptors (lone pair, p and s bonds). These cooperative non-covalent interactions provide efficient binding between the catalyst and substrate (~15 kcal/mol binding energy) and are the key factors for transition-state stabilization and molecular recognition.