Day 2 :
Keynote Forum
Don M Coltart
University of Houston, USA
Keynote: Stereocontrolled synthesis of chiral N- and O-heterocycles
Time : 09:30-10:15
Biography:
Don M Coltart has obtained his Master’s degree from the University of Manitoba under the supervision of Professor James L Charlton and then joined the research group of Professor Derrick L J Clive at the University of Alberta where he obtained his PhD. His Post-doctoral work was conducted at the Memorial Sloan-Kettering Cancer Center as NSERC, AHFMR, and CRI Scholar under the supervision of Professor Samuel J Danishefsky. He began his independent career at Duke University in 2004 and moved to the University of Houston in 2012 where he is an Associate Professor. His research group studies the development of methods for asymmetric carbon–carbon bond formation, the application of those methods to the total synthesis of structurally complex biologically active natural products and the study of those compounds in biological systems.
Abstract:
Nitrogen heterocycles are among the most important structural motifs found in natural products, drugs and related compounds. While many nitrogen-containing natural products contain chiral nitrogen heterocycles, relatively few drugs do despite being chiral themselves. In the latter case, this limitation is due in large part to a lack of reliable, effective and broadly applicable methods for the preparation of such heterocycles. However, as drug development moves away from the use of unsaturated (flat), structurally simple achiral compounds and seeks out more stereochemically sophisticated chiral compounds having higher degrees of saturation, the need for methods for the synthesis of chiral nitrogen/oxygen heterocycles has become increasingly important. In response to this, we have undertaken a research program aimed to the use of dipolar 3-heterofunctionalized azoalkenes for the synthesis of various saturated and partially saturated chiral nitrogen/oxygen heterocycles via novel annulation strategies. In this seminar, we will describe a variety of methods that we have been developed for the preparation of different 3-hetero-functionalized azoalkenes and their use in dipolar coupling reactions leading to a range of chiral nitrogen/oxygen heterocycles.
Keynote Forum
Richard M. W. Wong
National University of Singapore, Singapore
Keynote: Application of Halogen Bonding to Organocatalysis
Time : 10:15-11:00
Biography:
Richard Wong received his Ph.D. degree from Australian National University in 1989. Subsequently, he held postdoctoral position at IBM Kingston and Yale University. Currently, he is a full professor and head of department at the National University of Singapore. He was the recipient of Fukui Award recently on his outstanding work in theoretical and computational chemistry. Richard has published about 200 scientific publications, which received over 9300 citations and H-index of 43. His research interests include application of computational quantum chemistry to a range of chemical problems, include reactive intermediates, catalysis, materials design, chemical sensors, and weak intermolecular interactions. He is an international advisory board member of Asian Journal of Chemistry, Journal of Analytical and Applied Pyrolysis and Advanced Theory and Simulations.
Abstract:
Halogen bond, a noncovalent interaction involving a halogen atom as an acceptor of electron density, has emerged in recent years as an important element of molecular recognition and has numerous applications such as molecular self-assembly of functional materials and protein-drug interaction. Due to its bond strength and directionality, halogen bonding has great potential to become a complementary molecular tool to hydrogen bonding in rational catalyst design. Using density functional calculations, we have shown the use of halogen-bond donors as noncovalent activators in Lewis acid catalysis. In particular, we have proposed a new type of triaryl benzene organocatalysts via multiple halogen bond donors (e.g. perfluoro-iodophenyl group). This in silico designed halogen bonding (XB) based catalyst was applied to several important types of organic reaction, namely Diels-Alder reaction, Claisen rearrangement and cope-type hydroamination. The calculated catalytic mechanisms and activation barriers of these reactions readily demonstrate that the designed system is a promising Lewis acid catalyst via halogen bond mode of activation.[1] On the basis of our DFT calculations and calculated turnover frequencies, the XB-catalyzed reactions are found to be competitive with the corresponding hydrogen bonding catalysis reported in literature. The calculated transition states unravel multiple halogen bonds between the iodine atoms and various types of halogen bond acceptors (lone pair, p and s bonds). These cooperative non-covalent interactions provide efficient binding between the catalyst and substrate (~15 kcal/mol binding energy) and are the key factors for transition-state stabilization and molecular recognition.
- Inorganic Chemistry of Materials and Bio-Inorganic Catalysis
Session Introduction
Rong Chen
Wuhan Institute of Technology, China
Title: Crystal defect mediation for photocatalytic molecular oxygen activation and application
Time : 11:20-11:50
Biography:
Rong Chen has received his PhD in Inorganic Chemistry from the University of Hong Kong in the fields of Biological Inorganic Chemistry. Following a two-year Research Associate appointment, working at the University of Hong Kong, he has accepted a position as Professor of Applied Chemistry at Wuhan Institute of Technology. He is also the Dean of School of Chemistry and Environmental Engineering (2014-2017) at Wuhan Institute of Technology. His current research interest involves the development of novel functional nanomaterials with controllable sizes, unusual morphologies and interesting architectures that give rise to desirable properties and potential applications in environmental photocatalysis, water treatment, gas-phase catalysis, gas-sensors, antibacterial agents, etc.
Abstract:
The crystal defect is the region of parts of atoms being grown out of the periodic lattice structures peculiar to the crystal due to the external environment as it grows. For semiconductor materials, proper amount of crystal defects could greatly improve the photoelectric properties of materials, thus improving their catalytic activities. In this work, different crystal defects were successfully fabricated in bismuth-related nanomaterials by changing the reaction conditions, which realized the regulation of the activation of molecular oxygen, thus producing different reactive oxygen species (ROS). For example, the Z-scheme BiO1-XBr/Bi2O2CO3 photocatalytic system with rich in oxygen defects, Ce-doped Bi2MoO6 system, Bi-loaded BiPO4-X system and Br-O-Bi ternary defects cluster system. The construction of crystal defects in bismuth-related materials effectively improved the photocatalytic performance and showed a great potential in the application of the organic pollutants degradation and organic synthesis. The mechanism of the enhanced photocatalytic performance was also elucidated in depth.
Chunping Su
Wuhan Institute of Technology, China
Title: One-pot solvothermal synthesis of Bi/BiOBr mesh for visible-light-driven photocatalytic bacterial inactivation
Time : 11:50-12:20
Biography:
Chunping Su has completed her PhD, majored in Applied Chemistry from Wuhan Institute of Technology, China. Her research focuses on environmental catalytic
materials and functional interface materials. She has published three papers in international journals as the first author.
Abstract:
The emergence of pathogenic bacteria in surface water poses serious threats to public health worldwide, which commonly cause infectious waterborne diseases in human. Thus, it is one of the great importance to develop effective disinfection strategies for adequate inactivation of pathogenic microorganisms in water. In recent years, semiconductor photocatalysis has attracted growing interest as a promising technique for removal of bacterial contaminations owing to its powerful photocatalytic ability. However, the solid photocatalysts usually make the recovery inevitably depend on expansive separation processes. The great challenge of photocatalyst recovery severely limits their industry applications. Herein, Bi/BiOBr mesh with flower-like hierarchical microstructure was fabricated on the 304 stainless steel wire mesh substrates via a one-pot solvothermal route. This Bi/BiOBr mesh showed a rapid photocatalytic inactivation of >99.98% E. coli and >99.92% S. aureus in 180 min under visible light irradiation. More importantly, the Bi/BiOBr mesh was easily separated and recycled, which is a significant advance in comparison with the previously reported photocatalysts in form of powders and nanoparticles. Therefore, with a marvelous combination of facile fabrication, visible-light response and easy recycling characteristic, this novel photocatalyst is expected to have great potential applications in water purification and disinfection.
Huiping Zhao
Wuhan Institute of Technology, China
Title: The g-C3N4 surface-decorated Bi2O2CO3 for improved photocatalytic performance: From theoretical calculation to practical antibiotics photodegradation in actual water
Time : 12:20-12:50
Biography:
Huiping Zhao has completed her PhD from Wuhan Institute of Technology in 2017. Her current research is concentrated on developing novel bismuth-related
nanostructure materials for environmental remediation.
Abstract:
To overcome the issue of UV-light response character of Bi2O2CO3 due to its wide band gap, we attempted to improve the photocatalytic activity of Bi2O2CO3 through g-C3N4 surface-decoration, which was primarily evaluated by the theoretical analysis. Subsequently, g-C3N4 surface-decorated Bi2O2CO3 was successfully prepared via a facile hydrothermal method. It was found that all the g-C3N4 surface-decorated Bi2O2CO3 samples exhibited enhanced activities for antibiotic tetracycline photodegradation compared with pure Bi2O2CO3 upon simulated solar light irradiation, among which the 10 wt% g-C3N4 surface-decorated Bi2O2CO3 sample showed the highest efficiency. Both first principle calculation and experimental data confirmed that the charge transfered at the interface between g-C3N4 and Bi2O2CO3 could significantly suppress the recombination of photo-generated electron-holes pairs, thus improving the photocatalytic performance. The mechanism for the enhanced photocatalytic activity was also proposed by the electrochemical measurement and PL testification result. Moreover, the g-C3N4 surface-decorated Bi2O2CO3 was explored for antibiotics treatment in actual water.
- Poster Pressentation
Location: Le Foyer
Session Introduction
Dumitrela Cucu
Alexandru Ioan Cuza University of Iasi, Romania
Title: Quinoline derivatives anchored with imidazole moiety: Synthesis, structure and biological activity
Biography:
Dumitrela Cucu is a PhD student at Alexandru Ioan Cuza University of Iasi, under the supervision of Prof. Ionel Mangalagiu.
Abstract:
Quinoline and imidazole derivatives are invaluable scaffolds for medicinal chemistry. Pharmaceutical industry and modern medicinal chemistry pay a lot of effort in their combat with two aggressive life-threatening diseases: cancer and tuberculosis (TB). Both diseases are leading cause of death worldwide, millions of people dying every year, the incidence of both are continually increasing and the treatment became more and more complicated and sophisticated. The cancer chemotherapy is complex, expensive and often rather inefficient, because of the large variety of neoplasm types, high toxicity levels and non specificity of drugs, and the emergence of drug resistance and multi-drug-resistance (MDR). On the other hand, because of the Mycobacterium tuberculosis (Mtb) versatility, the treatment against TB became a challenging and difficult task and, the situation begin to be even worse because of the phenomena of drug resistance, MDR, extensively-drug-resistant (XDR), association of TB with AIDS, etc. As part of our ongoing research aiming the design and synthesis of novel anticancer and anti-TB derivatives with azaheterocycles skeleton, we report here the design, synthesis, structure and in vitro anticancer and anti-TB activity of some new quinoline derivatives bearing an imidazole moiety. The strategy adopted for synthesis is straight and efficient, involving a three step setup procedure: N-acylation, quaternization of nitrogen heterocycle and a [3+2] cycloaddition. The solubility in microbiological medium, anticancer and antimycobacterial activity of a selection of new synthesized compounds were evaluated. Some of the tested compounds have an excellent solubility in microbiological medium and exhibit a very good and selective antitumor activity against renal, breast and prostate cancer. (The assay was performed in a 60 human tumour cell line panel, representing leukemia, melanoma and cancers of lung, colon, brain, breast, ovary, kidney and prostate, in accordance with the protocol of the NCI). Some of the compounds shows very good antimycobacterial activity. SAR correlations have been performed.
FNU Shubhashish
University of Connecticut, USA
Title: Organic transformations utilizing gold supported transition metal oxide catalysts
Biography:
FNU Shubhashish obtained BS-MS dual degree in Chemistry from Indian Institute of Science Education and Research, Bhopal. Then in 2016 moved to USA, University of Connecticut for Doctoral studies in the Department of Chemistry under the supervision of Prof. Steven Suib. His work mostly focuses on Catalysis and its application in organic transformation.
Abstract:
Gold is a very expensive metal but at the same time using this as a catalyst plenty of organic reactions can be catalyzed. Hence to make this experimentally viable our idea was to develop novel catalysts where gold is being used as a supported metal. Keeping this in mind we synthesized various gold supported mesoporous transition metal oxide catalysts using the UCT method. We used XRD, SEM, TEM, BET, and XPS instruments for characterization. From XRD phase analysis we found that gold is getting doped into some of the catalytic systems. Mesoporosity was confirmed using BET surface area analysis and we observed some gold doped systems are more mesoporous than undoped ones. These catalysts were then utilized for a series of organic transformation reactions. We observed that most gold supported catalytic systems give improvement in selectivity and reactivity. This work is still in progress and we are trying to optimize the catalytic conditions and extend this work to many other organic transformation reactions.
Isabel S Aguirre-Díaz
Ciudad Universitaria, Mexico
Title: Protease-mediated syntheses of polypeptides in compressed 1,1,1,2-tetrafluoroethane media
Biography:
Abstract:
Protease from Subtilisin Carlsberg and liquid 1,1,1,2-tetrafluoroethane (R134a) mediated the syntheses of high molar mass poly(L-phenylalanine ethyl ester), poly(L-leucine ethyl ester) and copolymers of poly(L-phenylalanine ethyl ester-co-Lleucine ethyl ester) with yields of ca. 50%. This hydrophobic and relatively polar compressed fluid medium allows for the protease activity and solubilities of the amino acid esters and products. The homopolypeptides displayed higher crystallinity than the copolypeptides with random incorporation of both L-aminoacid ethyl esters. The affinity of the protease enzyme was significantly higher for L-phenylalanine ethyl ester than for the leucinate substrate. Secondary structure assessment by FTIR and Circular Dichroism indicates a non-common folding of peptides. Calculations using molecular dynamics, Flory-Huggins parameter and Gibbs energy of mixing to obtain insight on the solubility behavior of these systems predict that solutions of R134a and copolymer will be thermodynamically miscible at all the temperatures and volume fractions of copolymer studied. Additionally, R134a-polymer systems will present phase separation at specific temperatures and volume fractions of the polymer. The prediction also shows that the obtained copolypeptide is more soluble in R134a than the more crystalline homopolypeptides separately.
Min Sup Kim
Kwangwoon University, South Korea
Title: Comparative photovoltaic properties of novel thiophene and selenophene-based conjugated low bandgap polymers
Biography:
Min Sup Kim has completed his Undergraduate studies at Kwangwoon University, Department of Chemistry. He is currently working on Master's degree at Kwangwoon University and majoring in Polymer Chemistry.
Abstract:
In this study, we investigated the photovoltaic properties of newly synthesized low bandgap conjugated polymers, poly(4- (4,8-bis(5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b:4,5-b0]dithiophen-2-yl)-8-(5-(2,6-didodecylbenzo[1,2-d:4,5-d0]bis(thiazole)-4-yl)thiophen-2-yl)-2,6-didodecylbenzo[1,2-d:4,5d0] Bis(thiazole)(P1) and poly(4-(4,8-bis(5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b:4,5-b0]dithiophen-2-yl)-8-(5-(2,6-didodecylbenzo[1,2-d:4,5-d0 ]bis(thiazole)-4-yl)selenophen-2-yl)-2,6-didodecylbenzo[1,2-d:4,5d0] bisthiazole)) (P2). P1 is a thiophene-based conjugated polymer (TCP) and P2 is a selenophene-based conjugated polymer (SCP). These two different conjugated low bandgap polymers were characterized by NMR and gel permeation chromatography. The physical properties of the polymers were studied by thermogravimetric analysis and conductivity. Moreover, we also investigated the optical, electrochemical and morphological properties of both polymers by UV-vis spectroscopy, cyclic voltammetry and atomic-force microscopy (AFM), respectively. Later, we studied the photovoltaic properties of both low bandgap polymers blended with PC61BM in different ratios with different thicknesses. In addition, post thermal annealing at different temperature for both polymers was investigated and the results showed that P2 (SCP) exhibited stronger molecular orientation properties as compared to P1 (TCP).
Monirah Al-Alshaikh
King Saud University, Saudi Arabia
Title: Syntheses and crystal structures of two adamantylsubstituted 1,2,4-triazole-5-thione N-Mannich bases
Biography:
Monirah Al-Alshaikh has completed her PhD in Organic Chemistry in 1993. She is an Associate Professor from Chemistry Department, King Saud University. She
has published more than 36 papers in reputed journals.
Abstract:
In the title N-Mannich bases, 3-(adamantan-1-yl)-4-(4-fluorophenyl)-1-[(4-phenylpiperazin-1-yl)methyl]-4,5-dihydro-1H-1,2,4-triazole-5-thione (C29H34FN5S)(I), and 3-(adamantan-1-yl)-4-(4-fluorophenyl)-1-{[4-(2- methoxyphenyl) piperazin-1-yl]-methyl}-4,5-dihydro-1H-1,2,4-triazole-5-thione (C30H36FN5OS) (II), fluorophenyl, adamantane and piperazine moieties are linked to a planar triazole ring. There is an additional phenyl ring on the piperazine ring in (I) and a methoxyphenyl ring in (II). In compound (I), the fluorophenyl and phenyl rings are inclined to the triazole ring by 86.55 (13) and 60.52 (12)_, respectively, and the two aryl rings are inclined to one another by 66.37 (13)_. In compound (II), the corresponding dihedral angles are 83.35 (13), 71.38 (15) and 11.97 (16)_, respectively. The crystal structure of (I) shows pairs of C—H_ _ _F hydrogen bonds forming inversion dimers, while in the crystal of compound (II), in addition to the C—H_ __F hydrogen bonds that generate chains parallel to the b axis, there are C—H_ _ __ interactions present that link the chains to form layers parallel to the ab plane.
So Yon Lee
Chung-Ang University, South Korea
Title: Synthesis and characterization of a noncentrosymmetric layered bismuth tellurium oxide nitrate
Biography:
So Yon Lee has completed her Bachelor’s degree at Chung-Ang Univeristy and is currently on her Master’s degree at Chung-Ang University. She is advised by Prof. Kang Min Ok in the inorganic chemistry labratory. So, she is working on the synthesis and characterization of new noncentrosymmetric materials.
Abstract:
Materials crystallizing in noncentrosymmetric (NCS) structures may show certain properties such as pyroelectricity, piezoelectricity, ferroelectricity and nonlinear properties. To achieve a macroscopic NCS structure, bismuth, tellurium and NO3- were used in the synthesis as constituents. Since the lone pairs on bismuth and tellurium are stereochemically active, they can exhibit asymmetric environment. The π-conjugated electron in the NO3 group can also facilitate the nonlinear optical property. The hydrothermally synthesized material reveals a layered nonpolar structure with a weak hydrogen bond interaction. The compound crystallizes in the orthorhombic space group, P-21-21-21. Two types of existing telluriums, Te4+ and Te6+ show see-saw and octahedral coordination environment with oxide ligands, respectively. Bi3+ cations are linked to oxygen atoms and form BiO9 and BiO10 polyhedra. NO3- is connected to the bismuth atoms. Powder second-harmonic generation(SHG) measurements indicate that the NCS material has a SHG efficiency of 20 times that of α-SiO2
Violeta Mangalagiu
Stefan cel Mare University of Suceava, Romania
Title: New six member ring azaheterocycles with antileishmania activity
Biography:
Violeta Mangalagiu has completed her PhD at the University of Suceava (Romania), and Post-doctoral studies at the same university. Presently, she is a senior Researcher at Alexandru Ioan Cuza University of Iasi and Lecturer at University of Suceava. She has published more than 25 papers in reputed journals and has been serving as an Editorial Board Member of repute.
Abstract:
In recent years, six membered ring azaheterocycles have demonstrated extremely interesting potential applications in medicinal chemistry, such as anticancer, antibacterial, antituberculosis, antimicrobials, etc. Leishmaniasis is a growing health problem worldwide, cutaneous leishmaniasis being the most common form of leishmaniasis. Conventional treatments for cutaneous leishmaniasis are using classical drugs such as pentamide and imidazoquinolines. However, because of drug resistance, toxicity, side effects, relatively high cost, their use has become quite limited. As a result, the demands of pharmaceutical industry for new drug candidates with antileishmania activity is high. As part of our ongoing research in the area of azaheterocycles derivative with biological activity, we report here the design, synthesis, structure and in vitro antileishmania activity of new six membered ring azaheterocycles. In this respect our efforts was focused in the area of fused and non- fused azine, new compounds being designed, synthesized, characterized and tested in vitro for their antileishmania activity. Some of the compounds was also tested for antimalarial activity. The structures of the compounds were proved by elemental and spectral analysis: IR, MS, 1H-NMR, 13C-NMR, two-dimensional experiments 2D-COSY, HMQC, HMBC. The antileishmanial assay was performed against Leishmania donovani intramacrophage amastigotes. The obtained results showed us that some compounds have a very good and promising activity, some of the compounds being at least 10 times more active comparative with the witness, miltefosine. The results against Plasmodium faliciparum are modest.
Yan Yi Lee
National Changhua University of Education, Taiwan
Title: The use of isomeric normal and abnormal palladium NHC complexes in direct C5-arylation reaction
Biography:
Abstract:
We designed four series of isomeric palladium(II) complexes with normal and abnormal N-Heterocyclic Carbenes (NHCs) ligands. These complexes were characterized by 1H and 13C NMR spectroscopy, elemental and X-ray crystallography. Their potential application as catalysts in direct C5-arylation reaction between imidazoles and aryl halides were investigated. Using a mere 0.5 mol % Pd loading, coupled products were obtained with moderate to excellent yields. Normal NHCs complexes have better catalytic activity than their abnormal counterpart. DFT calculations were performed to explain the difference.
Biography:
Barbara Wołek graduated from the Jagiellonian University in Modern Organic Synthesis and Physical Chemistry as well as in Geochemistry, Petrology and Mineralogy. Since 2009 she has been working at Selvita; currently a Team Leader at the Contract Chemistry Division. She has deep knowledge of organic chemistry, and significant know-how in route and process optimization, scale-up, library synthesis, heterocyclic chemistry, metal-catalyzed cross coupling reactions, carbonylation, asymmetric synthesis and many others. she has acquired considerable experience working in multidisciplinary teams in the area of drug discovery, designing and synthesizing molecules to build knowledge about SAR and to improve their properties.
Abstract:
A new efficient and safe method for inversion of configuration of chiral amines has been developed.Several homochiral amine synthons were synthesized. Two of them (Cinacalcet and Rivastigimine) were converted into di-tosyl and di-mesyl derivatives. Inversion of configuration of the chiral center was achieved by substitution of the disulfonimide moiety using NaN3 under flow conditions to give an organic azide. The reaction has been fully optimized (temperature, flow rate and solvent) in a flow reactor, which ensured the safety of the whole process. The organic azides were obtained in satisfactory yields and over 90% ee. The azides could be reduced to the desired amines by standard hydrogenation, which should also be achievable under flow conditions. We also intend to expand the method to other amines to make it as widely applicable as possible.
Eun Jeong Cho
Chung-Ang University, South Korea
Title: Hydrothermal synthesis, crystal structure, and second-harmonic generating (SHG) properties of a new layered bismuth oxyfluoride nitrate
Biography:
Eun Jeong Cho has obtained her Bachelor’s degree from Chung-Ang University. She is working on the synthesis and characterization of new bismuth oxyfluoride
materials as a graduate student under the guidance of Prof. Kang Min Ok at Chung-Ang University.
Abstract:
A new layered noncentrosymmetric (NCS) bismuth oxyfluoride-nitrate was synthesized by a hydrothermal reaction. The crystal structure was determined by powder and single-crystal X-ray diffraction. The material crystallizes in an NCS trigonal space group, R3 (No. 146). The constituting [Bi6O7F3]+ cationic layer contain H2O and nitrate anion makes a charge balance. The powder second harmonic generation (SHG) measurements indicate the title compound is phase-matchable (Type I) and exhibits a strong SHG efficiency of about 90 times that of α-SiO2. Detailed structural examination suggests that the π-conjugate system of nitrate anion directly influence the nonlinear optical (NLO) properties of the material. Infrared and UV–vis diffuse–reflectance spectroscopy, energy dispersive X-ray spectroscopy (EDS), thermogravimetric analysis (TGA), and local dipole moment calculations are also presented.
Hye Rin Song
Chung-Ang University, South Korea
Title: Hydrothermal synthesis, structure determination, and characterization of a noncentrosymmetric europium iodate
Biography:
Hye Rin Song obtained her bachelor degree at Daejeon University. Hye Rin is working on the synthesis and characterization of new europium iodate materials
under the guidance of Prof. Kang Min Ok at Chung-Ang University.
Abstract:
A new noncentrosymmtric europium iodate has been synthesized through a hydrothermal reaction using Na2CO3, Eu(NO3)∙6H2O, HIO3, and water as reagents. The crystal structure of the newly synthesized iodate was determined by single-crystal X-ray diffraction. The material crystallizes in the rhombohedral space group, R3c (No. 161) with the unit cell parameters of a = b = 21.968(4) Å and c = 13.363(3) Å. The iodate material reveals three-dimensional framework consisting of EuO8, IO3, and IO4 polyhedra. The IO3 and IO4 polyhedra are in asymmetric coordination environment due to the stereochemically active lone pairs.Full characterization including energy dispersive X-ray spectroscopy (EDS), thermogravimetric analysis (TGA), second-harmonic generation (SHG) measurements, infrared, and UV–vis diffuse–reflectance spectroscopy are also presented.