Cordelia Dueke-Eze
University of Lagos
Title: Exploring the Antituberculosis Potential of Schiff Base Transition Metal Complexes: Synthesis and Characterisation of Copper(II) and Cobalt(II) Complexes of 5-(Substituted-salicylidene)aminopyridine
Biography
Biography: Cordelia Dueke-Eze
Abstract
Treatment of tuberculosis (TB) still remains an important and challenging problem because of a combination of factors including increasing number of multi-drug resistance to the existing tuberculosis drugs and co morbidity of TB with HIV. The World Health Organization recently reported TB as one of the leading cause of death from infectious disease especially in Africa. Discovery of new compounds with anti-tuberculosis (anti-TB) effect and possibly with mechanism of action different from those of well known TB drugs is highly desirable. Schiff bases and their metal complexes represent major investigational compounds. The Schiff bases were obtained by the condensation reaction of salicylaldehyde with 2 (L1-L4) and 4- aminopyridine (L4-L7). They were reacted with CuCl2.H2O and CoCl2.6H2O to form Cu(II) and Co(II) complexes. 1H, 13C NMR, IR, electronic absorption and elemental analysis confirm the formation of the ligands. The metal complexes were also characterised on the basis of various spectroscopic techniques. The compounds were screened for their anti-TB activity using the proportion method and isoniazid (INH) as a reference compound. The complexes showed enhanced in-vitro anti-tuberculosis activity against Mycobacterium tuberculosis H37RV compared to the free ligands and the reference compound (INH). Co(II) complex containing the nitro substituent exhibited significant anti-TB activity with an MIC of 0.05 µg/mL. The results demonstrate that compounds with imine group and metal ion can display strong anti-TB activity making them suitable as lead compound in the development of new TB drugs.