Dorina Amariucai-Mantu
Alexandru Ioan Cuza University
Title: New bis-pyridazine derivatives: synthesis, structure and their potential interest in Leishmaniasis
Biography
Biography: Dorina Amariucai-Mantu
Abstract
Leishmanisis is a parasitic disease which affects over one million people worldwide. It is transmited by certain types of sandflies and is closely associated with poverty. The most common form of the disease is the cutaneous Leishmaniasis. Current treatments, including pentamidine and imidazoquinolines, are used for treatment of cutaneous disease, however, they have some limitations due tue their toxicity, relatively high cost and drug resistance.
Nitrogen heterocyclic compounds are invaluable constituents of molecules with various biological importance, being essential components in drug designing programs.
The emphasis of the current research work consists in the design, synthesis, characterization and antileishmanial activity evaluation of a new class of nitrogen heterocyclic derivatives, new bis-pyridazine molecules (BP), structurally related to pentamidine.
Three new classes of BP-derivatives were designed (BP I-III), their synthesis being straightforward and efficient. The BP-I derivatives were obtained through an N-alkylation of the starting BP heterocycle, which subsequently, by substitution with hydrazine conducted to BP-II derivatives. A final condensation with aromatic aldehydes yielded the BP-III class of compounds.