Julie Chineze Obi
Chukwuemeka Odumegwu Ojukwu University
Title: Synthesis of new analogues of natural product antheminone A and evaluation of their anti-cancer activity
Biography
Biography: Julie Chineze Obi
Abstract
Synthesis of two new analogues (1a) and (1b) of a natural product antheminone A (1c) and their evaluation of anti-cancer activities are hereby described. The synthesis involved a multi-step reaction sequence involving the use of natural product (-)-quinic acid (1d) as a precursor. The compounds which were obtained in good to moderate yields (51-67%) exhibited toxicity towards the non-small cell lung cancer cell line, A549.