Senem Akkoç
Süleyman Demirel University, Turkey
Title: Biological activity evaluation of a series of 1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-alkylbenzimidazolium salts
Biography
Biography: Senem Akkoç
Abstract
In the past few decades, infections caused by multi-drug resistant bacteria have increased at frightening levels all over the world. Microbial infections are a growing health problem in modern medicine and the use of antibiotics is widespread in the worldwide. In particular, infections caused by the Gram-positive bacterium Staphylococcus aureus and species of the genus Enterococcus have become a major worldwide health problem due to their ability to develop resistance to multiple antibiotics. To overcome these emerging resistance problems, there is an urgent need to discover novel chemotherapeutic agents, which have a broad spectrum of activity and, if possible, with new modes of action. A series of benzimidazolium salts were synthesized and their structures were completely verified by means of elemental analysis, FT-IR, 1D NMR: 1H NMR, 13C NMR. The biological activities of these salts were examined and were found to show moderate activity. The synthesized n-butyl substituted salt displayed the best activity against A. hydrophila, P. aeruginosa, E. coli, S. aureus and L. monocytogenes as Gram +/- microorganisms. The synthesized ethyl substituted salt showed significant activity compared to the other salts against S. typhimurium and Y. enterocolitica. Finally, it could be concluded that nearly all compounds exerted moderate antibacterial activity.