Organic and Inorganic Chemistry

Carbon-carbon bond formation is a fundamental transformation in synthetic organic chemistry. Hence, many transformations leading to C-C bond formation have been developed and then used in synthesis of simple and complex molecules. In recent years considerable attention has been given to increase the efficiency of organic synthesis, particularly by reducing of chemical waste and production cost. One option to meet these criteria are domino reactions. This method involves the formation of several bonds under the same reaction conditions without adding additional reagents, catalysts, or isolating the reaction intermediates.1 With respect to our previous research,2 we turned our attention to OxoTriphenylHexanOates (1, OTHOs) due to their easy accessibility via a threecomponent ionic liquid promoted reaction. The treatment of corresponding OTHOs with boron tribromide lead to the formation of tetracyclic molecules 2, in good yields of up to 74%, via the reaction sequence involving the formation of three new C-C bonds.