Weiguo Cao
Shanghai University, China
Title: Efficient and stereoselective synthesis of trifluoromethylated pyrano[3,4-c] pyrrole derivatives
Biography
Biography: Weiguo Cao
Abstract
Fused pyrroles are ubiquitous motifs in a substantial number of naturally and non-naturally occurring compounds and can often serve as “privileged structures” in medical and pharmaceutical chemistry. Among them, pyrano[3,4-c]pyrrole derivatives have aroused interest owing to their biological activities. Herein, we report the efficient and stereoselective synthesis of trifluoromethylated pyrano[3,4-c]pyrroles via three-component bicyclization process. We performed the reaction by employing 3-aroylacrylic acids 1, methyl 4,4,4-trifluorobut-2-ynoate 2 and tert-butyl isocyanide 2 in MeCN. After stirring for 12 h at 80ï‚°C, a series of trifluoromethylated pyrano[3,4-c]pyrroles 4 were synthesized in good to excellent yields