Wei Zhou
Shanghai University, China
Title: Novel synthesis of perfluoroalkylated pyrrolo[2,1-a]isoquinolines via a dipea-promoted one-pot process
Biography
Biography: Wei Zhou
Abstract
Pyrrolo[2,1-a]isoquinoline derivatives is a kind of compound with good fluorescence properties and also a kind of very important alkaloids having good biological activities. Therefore, the synthetic methodologies for constructing these compounds are highly demanded. DIPEA-promoted one-pot two-step threecomponent reaction for the synthesis of pyrrolo[2,1 a]isoquinoline has been achieved. In this paper, a series of perfluoroalkylated pyrrolo[2,1-a]isoquinoline derivatives (4) were synthesized by the reaction of isoquinolines (1), bromomethyl ketones (2) and methyl perfluoroalk-2-ynoates (3) in the presence of DIPEA (Scheme 1). This procedure is compatible with a broad range of functional groups in both pyridines and bromomethyl ketones with moderate to good yields.