Organic and Inorganic Chemistry

In recent decades, new drug delivery systems that have vital applications in targeted and specialized therapies are on the rise. These researches have provided a good basis for the use of new carriers, including the porous metal-organic framework (MOF), in targeted drug delivery systems. In this research, the magnetic MIL-100 was prepared using the hydrothermal methods. Also, these nanostructures were coated with folate-chitosan. The obtained magnetic carriers characterized by various techniques such as X-ray diffraction, field emission-scanning electron microscopy, transmission electron microscopy, vibrating sample magnetometer and Fourier transform infrared. The effect of hydrothermal conditions e.g. temperature, solvent and metal to ligand ratio on the morphology and size of prepared nanocomposites have been investigated. The sizes of magnetic nanoparticles have an impact effect on the drug encapsulation efficiency and release performance. The in-vitro release of curcumin from MIL-100@Fe3O4/chitosan carriers was investigated. Curcumin was efficiently released from magnetic carriers into environment under acidic pHs.