Wafa A. Bawazir
King AbdulAziz University, Saudi Arabia
Title: Synthesis of novel class of fluorinated macrocyclic compounds as Ru-Complexes and their CDK2 inhibition activity
Biography
Biography: Wafa A. Bawazir
Abstract
During last decade, many classes of azathio crown macrocycles containing two 1,2,4-triazine rings as bioactive subunits have been approached for building of a new chemotherapy antitumor drugs. Sun et al. prepared a stable type of ruthenium complexes containing 3-amino-1,2,4-triazino[5,6-f]1,10-phenanthroline and reported their electrochemical and photophysical properties. Based on these facts, the purpose of this work is to extend and explore more on the scope of our previous studies fluorine substituted 1,2,4-triazines heterocyclic rings was used in order to enhance the complex as CDK2 inhibitors of tumor cell. Novel fluorinated class of cyclic aza-oxo crown macrocyclic systems containing 1,2,4-triazinone moieties (6) and their Ru-complexes 7 have been obtained from the interaction between 5,6-di(4-fluorophenyl)-3-mercapto-1,2,4-triazine (1) with 2,6-diaminopyridine (2) followed by ring closer reaction with diethyl oxalate and reflux with RuCl3.xH2O in N,N-dimethylaniline to afford the Ru-complex. Structures of the products were deduced from their elemental analysis and spectral measurements.