Hossein Mostafavi
University of Tabriz ,Iran
Title: Synthesis and biological evaluation of novel 3,4,5-trihydroxy benzoic acid derivatives
Biography
Biography: Hossein Mostafavi
Abstract
A diversity of biological activities and pharmaceutical uses have been attributed to phenolic acid derivatives such as antibacterial, anticancer, antiinflammatory (1-3).
A series of 3,4,5-trihydroxy benzoic acid derivatives were synthesized and their structure confirmed by FT-IR, 1HNMR, 13CNMR, elemental analysis.
In vitro biological activity of compounds was determined against proteus vulgaris ATCC 7829, Escherichia coli ATCC 25922, as (Gram-negative) bacteria and bacillus cereus ATCC 11778, Staphylococus aureus ATCC 6538 as (Gram-positive) bacteria. Antibacterial susceptibility tests was done by use of the paper disc diffusion method on Mueller Hinton agar (Merck). Chloramiphenicol, Penicilline, Streptomycin and Tetracycline were standard reference antibiotics. The zone of inhibition against bacteria was mearsured after 24 hours at 37°C. Compounds 3, 4, 5 were the main antibacterial compounds against Gram-negative bacteria but not Gram-positiv.